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Megafreak Supplements Blog

SARMs Talk - GW 501516

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SARMs, what are they? Why should you care? In this series of blogs I look to give you the honest and straight forward answers to this with science to back it up!

So let’s start with GW 501516 which is marketed alongside other SARMs, however it is actually a PPAR modulator (more on this later!).

What is GW 501516 and where did it come from?

Some background, GW was initially developed by GlaxoSmithKline and Ligand Pharmaceuticals as a cure or at least treatment for Hyperlipidemia. What is Hyperlipidemia I hear you collectively cry! Well, it is the hyper elevated levels of lips or lipoproteins in blood, which can lead to many health issues such as diabetes, cardiovascular disease abd acute pancreatitis, generally most of the ailments associated with obesity.

Testing continued until it was discontinued in 2007, this was put down to a single study on rats which showed an increased risk of Cancer, the main issue here however is the dosing. The dosing in the study was 3mg/Kg/day for the majority of their lifetime without any break. There is a massive disconnect there between the dosing in the study and what a human would use, for example I am 112KG in bodyweight, therefore the suggestion here is that I would use 336mg every single day of GW 501516 for roughly 2/3rds of my life! The reality is I would use 20mg a day for no more than 12 weeks without a break! You can now see how the study simply makes no sense.

So what is the performance enhancement form GW 501516 I keep hearing about?

One of the side effects of GW 501516 is that it massively increases endurance in athletes in addition to the obvious fat loss benefits. This came to light prior to the 2008 Olympic Games and saw the IOC look to set up a urine test to detect GW 501516 with WADA adding it to the prohibited list in 2009 and classifying it as an ‘ergogenic performance enhancing drug’ meaning if you take part in a tested sport I’d probably give it a miss!

How does GW 501516 work?

Sorry, it is going to get a little science based now but we will try to keep things easy to get our heads round! As noted GW 501516 is a PPAR agonist and directly effects the coactivator PGC-1a which is known to upregulate the use of proteins in energy output. This also leads to an increase in skeletal muscle fatty acid metabolism (fat burning) which reduces the onset of Type2 Diabetes, this is coupled with an increase in HDL (Good fats) and a lowering of LDL (bad fats) while also increasing glucose uptake in the muscle. This basically all means:

  • More endurance
  • Increased fat burning
  • Reduced risk of Type 2 Diabetes
  • Increased good fats
  • Decreased bad fats
  • Increased glucose uptake in muscles

There is some real big benefits listed there, even from a purely health related view!

Is GW 501516 safe then?

Yes is the simple answer here, at the dosing of 20mg a day there is no evidence of any negativity at all, in addition to alleviate the concerns form the aforementioned cancer scare, the more recent studies show that GW 501516 actually inhibited the growth of cancer cells, and and could potentially be used to combat cancer!

Can GW 50516 be stacked with other SARMs or AAS?

Yes is the short answer, GW 501516 stacks brilliantly with Ostarine giving ways to some excellent lean muscle gains while keeping fat at a minimal level. Regarding AAS GW 501516 is ideal to use alongside Trenbolone as many of the negative physical side effects can be combated (cholesterol issues for example), as an additional bonus to this there is the rather excellent fact that it will enhance many of the positives of Trenbolone too!

In Conclusion

GW 501516 is simply one of my favourite products on the market today, useful when bulking, insanely useful when cutting and in general a great option! Recommendation is 10 – 20mg per day for 12 weeks then a 4 – 6 week rest is taken. 

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